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KMID : 0383820100690060426
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Tuberculosis and Respiratory Diseases
2010 Volume.69 No. 6 p.426 ~ p.433
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Infection Rate of Chlamydia pneumoniae in Patients with Chronic Cough
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Chun Seung-Yun
Park Kwon-Oh
Park Yong-Bum
Choi Jeong-Hee
Lee Jae-Young
Mo Eun-Kyung
Park Sung-Hoon
Kim Cheol-Hong
Lee Chang-Youl
Hwang Yong-Il
Jang Seung-Hun
Shin Tae-Rim
Park Sang-Myeon
Kim Dong-Gyu
Lee Myung-Goo
Hyun In-Gyu
Chung Ki-Suck
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Abstract
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Background : Persistent cough has recently been found to be associated with Chlamydia pneumoniae infection. We aimed to investigate the infection rate of C. pneumonia in adult patients with chronic cough.
Materials and Methods : We recruited 68 patients with persistent cough lasting in excess of 3 weeks, who visited Kangdong Sacred Heart Hospital from January 2005 to August 2005. On the first visit, chest and paranasal sinuses radiography, skin prick test of common allergens, and induced sputum samples for C. pneumoniae were performed in all of patients. Further evaluation for diagnosis included a methacholine provocation test and eosinophil counts in induced sputum.
Results : The most common cause of chronic cough was upper airway cough syndrome (UACS) (26.5%), followed by eosinophilic bronchitis (20.6%) and cough variant asthma (16.2%). Idiopathic chronic cough was the cause in 33.8% of patients. The mean duration of cough was 11.7 months. C. pneumoniae was isolated by polymerase chain reaction (PCR) from one patient who had upper respiratory air way syndrome.
Conclusion : Chlamydia pneumoniae appears to have a minor role as a cause of chronic cough in patients.
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KEYWORD
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Cough, Polymerase Chain Reaction, Chlamydia Infections
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